Definition of left ventricular dilation in heart failure using cardiovascular magnetic resonance: prognostic implications of end-diastolic diameter and volume assessment

Abstract Background Patients with heart failure (HF) and reduced or mildly ejection fraction (HFrEF/HFmrEF) display variable grades of left ventricular (LV) dilation. LV end-diastolic diameter (LVEDD) volume (LVEDV) may not be concomitantly increased. The respective prognostic implications dilation have been explored. Purpose To assess the LVEDD LVEDV index (LVEDVi) in HFrEF/HFmrEF. Methods Data from consecutive HF outpatients undergoing cardiovascular magnetic resonance (CMR) <50% were analyzed. was measured a basal short axis slice. Established age- gender-specific cut-offs for LVEDVi cut-off 58 mm used to define followed occurrence combined endpoint death hospitalization. Results A total 564 patients (79% men, median age 65 years [56–73], ischaemic aetiology 32%) included. HFrEF present 85% patients, HFmrEF 15%. Median values 63 (58–69) 124 mL/m2 (104–149) respectively. significantly correlated (r=0.804, p<0.001). Sixty-nine percent had concomitant based on LVEDVi. In contrast, 18% did concordant definition LVEDD, including 14% small large associated shorter survival free CV hospitalization (log-rank 4.6, p=0.032), while >58 (p=0.278). There trend toward an independent association between outcome adjusting HFrEF/HFmrEF status (hazard ratio 2.10, 95% confidence interval 1.00–4.41, p=0.050). An found LVEDD. >66 increased risk spline curve analysis (Figure 11). All also Conclusions HFmrEF, does always coincide dilated value excess is much larger than clinical practice. However, LVEDVi, add stratification. Funding Acknowledgement Type funding sources: None.